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Phenotypes Associated with This Genotype
Genotype
MGI:4819842
Allelic
Composition		 Nf2tm2Gth/Nf2tm2Gth
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Yap1tm1.1Dupa mutation (2 available); any Yap1 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver/biliary system phenotype ( J:162628 )
N
• liver is as enlarge as in Nf2tm2Gth/Nf2tm2Gth Tg(Alb-cre)21Mgn mice
• bile over-proliferation observed in Nf2tm2Gth/Nf2tm2Gth Tg(Alb-cre)21Mgn mice is suppressed

neoplasm
neoplasm ( J:162628 )
N
• mice do not develop bile duct hamartomas or hepatocellular carcinoma unlike Nf2tm2Gth/Nf2tm2Gth Tg(Alb-cre)21Mgn mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory