Phenotypes Associated with This Genotype

Genotype
MGI:4819845

• Allelic Composition: Nf2^tm2Gth/Nf2^tm2Gth; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

bile duct hyperplasia ( J:162628 )

bile duct proliferation ( J:162628 )

abnormal liver morphology ( J:162628 )

• at E18.5, multiple tubular structures surround each portal vein unlike in wild-type mice

enlarged liver ( J:162628 )

increased hepatobiliary system tumor incidence ( J:162628 )

• mice exhibit widespread bile duct hamartomas that expand into the deep liver parenchyma unlike wild-type mice

increased hepatocellular carcinoma incidence ( J:162628 )

• at 1 year of age

neoplasm

increased hepatobiliary system tumor incidence ( J:162628 )

• mice exhibit widespread bile duct hamartomas that expand into the deep liver parenchyma unlike wild-type mice

increased hepatocellular carcinoma incidence ( J:162628 )

• at 1 year of age

endocrine/exocrine glands

bile duct hyperplasia ( J:162628 )

bile duct proliferation ( J:162628 )

growth/size/body

enlarged liver ( J:162628 )