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Phenotypes Associated with This Genotype
Genotype
MGI:4820719
Allelic
Composition
Prkdchanky/Prkdchanky
Genetic
Background
either: C57BL/6JAnu or (involves: C57BL/6JAnu * CBA/CaJ)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdchanky mutation (2 available); any Prkdc mutation (417 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• typhlitis
• marked lymphocytic colitis

hematopoietic system
• mice that develop interstitial pneumonia also exhibit bone marrow myeloid hyperplasia
• mice that develop mild interstitial pneumonia also exhibit bone marrow myeloid hyperplasia
• plasma cell hyperplasia of the mesenteric lymph nodes

immune system
• typhlitis
• marked lymphocytic colitis
• mice that develop interstitial pneumonia also exhibit bone marrow myeloid hyperplasia
• plasma cell hyperplasia of the mesenteric lymph nodes
• reactive mesenteric lymph nodes with plasma cell hyperplasia
• reactive mesenteric lymph nodes with plasma cell hyperplasia
• mice that develop mild interstitial pneumonia also exhibit foci of mixed centrilobar inflammation in the liver
• some affected mice exhibit mild bronchointerstitial pneumonia, with infiltrates composed predominantly of lymphocytes with lesser numbers of neutrophils

liver/biliary system
• mice that develop mild interstitial pneumonia also exhibit foci of mixed centrilobar inflammation in the liver

respiratory system
• some affected mice exhibit mild bronchointerstitial pneumonia, with infiltrates composed predominantly of lymphocytes with lesser numbers of neutrophils


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory