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Phenotypes Associated with This Genotype
Genotype
MGI:4821384
Allelic
Composition		 Tg(Prnp)a20Cwe/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp)a20Cwe mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to prion infection ( J:130657 , J:143528 )
• following inoculation with RML scrapie prion, mice exhibit more rapid scrapie development and spread with axonal degeneration compared with similarly treated wild-type mice (J:130657)
• mice inoculated with mouse-adapted Rocky Mountain Laboratory prions develop scrapie after 74 +/- 6 days compared to wild-type mice that develop scrapie after 170 +/- 12 days (J:143528)

nervous system
axon degeneration ( J:130657 )
• following inoculation with RML scrapie prion

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory