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Phenotypes Associated with This Genotype
Genotype
MGI:4821388
Allelic
Composition		 Prnptm2Edin/Prnptm2Edin
Tg(Prnp)a20Cwe/0
Genetic
Background		 B6.Cg-Prnptm2Edin Tg(Prnp)a20Cwe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2Edin mutation (7 available); any Prnp mutation (142 available)
Tg(Prnp)a20Cwe mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal precursor proliferation ( J:107170 )
• cultured adult neural precursors exhibit increased proliferate compared with wild-type cells

cellular
abnormal neuronal precursor proliferation ( J:107170 )
• cultured adult neural precursors exhibit increased proliferate compared with wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory