Phenotypes Associated with This Genotype

Genotype
MGI:4821407

• Allelic Composition: Prnp^tm1Cwe/Prnp^tm1Cwe; Tg(Lck-Prnp)33Cwe/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus hypoplasia ( J:129512 )

• at 10.5 weeks

increased CD8-positive, alpha-beta T cell number ( J:129512 )

• the number of immature CD8+ T cells is increased compared to in wild-type mice

increased gamma-delta T cell number ( J:129512 )

• slight

hematopoietic system

thymus hypoplasia ( J:129512 )

• at 10.5 weeks

increased CD8-positive, alpha-beta T cell number ( J:129512 )

• the number of immature CD8+ T cells is increased compared to in wild-type mice

increased gamma-delta T cell number ( J:129512 )

• slight

endocrine/exocrine glands

thymus hypoplasia ( J:129512 )

• at 10.5 weeks