Phenotypes Associated with This Genotype

Genotype
MGI:4821783

• Allelic Composition: Cacng2^tm1.1Mwa/Cacng2^tm1.1Mwa
• Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:163029 )

• 73% of control mouse body weight at 8-10 weeks of age

behavior/neurological

head bobbing ( J:163029 )

• head lifting

abnormal locomotor coordination ( J:163029 )

ataxia ( J:163029 )

• ataxic gait

abnormal gait ( J:163029 )

• ataxic gait

nervous system

decreased excitatory postsynaptic current amplitude ( J:163029 )

• peak amplitude of climbing fiber EPSCs is reduced relative to controls

reduced AMPA-mediated synaptic currents ( J:163029 )

• AMPA receptor mediated currents are reduced