skeleton
• mice exhibit reduced tibial periosteal and endosteal circumference compared with wild-type mice
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• mice exhibit a reduction in total body bone mineral content compared with wild-type mice
• tibia bone mineral content is decreased compared to in wild-type mice
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• mice exhibit decreased total bone mineral density compared with wild-type mice
• however, mice exhibit normal tibial total and cortical bone mineral density
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limbs/digits/tail
• mice exhibit reduced tibial periosteal and endosteal circumference compared with wild-type mice
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