Phenotypes Associated with This Genotype

Genotype
MGI:4829794

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Tg(Nes-cre)1Atp/0
• Genetic Background: involves: 129S4/SvJae * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:73255 )

• die shortly after birth

nervous system

abnormal brain morphology ( J:73255 )

• cells from mutant brains are larger

abnormal cortical ventricular zone morphology ( J:73255 )

• increase in cell proliferation in the ventricular zone of E14.5 mutant telencephalon

• decrease in cell death in the ventricular zone of E14.5 mutant telencephalon

increased brain size ( J:73255 )

increased brain weight ( J:73255 )

• brain weight is increased at E14, E18, and at birth

• brain weight at birth is double that of wild-type

abnormal brainstem morphology ( J:73255 )

• nuclei in the brainstem are not identifiable

abnormal hippocampus layer morphology ( J:73255 )

• the laminar pattern of the hippocampus is disturbed

abnormal cerebellum morphology ( J:73255 )

• the laminar pattern of the cerebellum is disturbed

absent cerebellar foliation ( J:73255 )

increased neuronal precursor cell number ( J:73255 )

• cortex cells from E14.5 brains cultured at moderate or clonal density exhibit a significantly greater number of neurospheres than wild-type cells, indicating an increase in stem/progenitor cells in mutants

vision/eye

eyelids open at birth ( J:73255 )

growth/size/body

megacephaly ( J:73255 )