Phenotypes Associated with This Genotype

Genotype
MGI:4830344

• Allelic Composition: Reck^tm1Ito/Reck^tm1Ito
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:163845 )

• at E10.5, the series of periodically spaced contact zones in the pernineural vascular basement membrane compared to in wild-type mice

dilated vasculature ( J:163845 )

• at E10.5

hemorrhage ( J:163845 )

• at E10.5, mice exhibit abdominal hemorrhage unlike wild-type mice

embryo

abnormal vitelline vascular remodeling ( J:163845 )

• yolk sacs exhibit irregularly shaped sprouts or branches instead of the numerous small holes in the arterial domain observed in wild-type mice

• in the lateral regions, arteries are winding and variable in thickness compared to in wild-type yolk sac