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Phenotypes Associated with This Genotype
Genotype
MGI:4830718
Allelic
Composition		 Emx1tm1Sia/Emx1tm1Sia
Emx2tm1Sia/Emx2+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1Sia mutation (1 available); any Emx1 mutation (34 available)
Emx2tm1Sia mutation (1 available); any Emx2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebral cortex morphology ( J:163926 )
• interneurons are scarce in the cortex due to a failure of their tangential migration compared to in wild-type mice
abnormal embryonic/fetal subventricular zone morphology ( J:163926 )
• failure of interneurons to migrate into the cortex leads to hyperplasia of ganglionic eminences compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory