Phenotypes Associated with This Genotype

Genotype
MGI:4834610

• Allelic Composition: Gria2^tm1Rod/Gria2^tm1Rod
• Genetic Background: B6.129-Gria2^tm1Rod/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to neuronal excitotoxicity ( J:104951 )

• increased vulnerability to AMPA receptor-mediated excitotoxicity

• abolished AMPA receptor-mediated cell death in cultured motor neurons by the external polyamine 1-naphtyl acetyl spermine (NAS)

abnormal AMPA-mediated synaptic currents ( J:104951 )

• high degree of inhibition by the external NAS, a strong inward rectification and a high relative Ca2+ permeability

• higher elevations of the intracellular Ca2+ concentration upon AMPA receptor stimulation

• normal number of AMPA receptors in the cell membrane

behavior/neurological

abnormal response to novel object ( J:104951 )

• reduced object exploration

impaired coordination ( J:104951 )

• unable to walk on a rotarod

decreased grip strength ( J:104951 )

• slightly lower grip strength in fore limbs

abnormal limb posture ( J:104951 )

• abnormal posturing of both forelimbs and hind limbs during manipulations

decreased locomotor activity ( J:104951 )

• reduced spontaneous activity during the night

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:104951 )

• increased vulnerability to AMPA receptor-mediated excitotoxicity

• abolished AMPA receptor-mediated cell death in cultured motor neurons by the external polyamine 1-naphtyl acetyl spermine (NAS)

cellular

increased susceptibility to neuronal excitotoxicity ( J:104951 )

• increased vulnerability to AMPA receptor-mediated excitotoxicity

• abolished AMPA receptor-mediated cell death in cultured motor neurons by the external polyamine 1-naphtyl acetyl spermine (NAS)