Phenotypes Associated with This Genotype

Genotype
MGI:4834663

• Allelic Composition: Cacna1a^tg-rol/Cacna1a^tg-rol
• Genetic Background: involves: C3Hf/Nga * C57BL/6 * SIII

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:3611 )

homeostasis/metabolism

increased noradrenaline level ( J:164122 )

• noradrenaline level is significantly elevated in the cerebellum

abnormal glucose homeostasis ( J:3611 )

• mice show marked increases in local cerebral glucose utilization in the structures of the basal ganglia such as globus pallidus, entopeduncular nucleus, substantia nigra pars compacta and pars reticulata, and subthalamic nucleus, and some increase in the limbic system and brainstem such as the CA1 and CA3 region of the hippocampus, lateral habenula, pedunculopontine nucleus, red nucleus, and ventral tegmental area, indicating a basal ganglia dysfunction

• no alternation in local cerebral glucose utilization in the cerebellum

nervous system

small cerebellum ( J:164122 )

• cerebellum wet weight is 76% of controls

abnormal nervous system physiology ( J:3611 )

• mice show marked increases in local cerebral glucose utilization in the structures of the basal ganglia such as globus pallidus, entopeduncular nucleus, substantia nigra pars compacta and pars reticulata, and subthalamic nucleus, and some increase in the limbic system and brainstem such as the CA1 and CA3 region of the hippocampus, lateral habenula, pedunculopontine nucleus, red nucleus, and ventral tegmental area, indicating a basal ganglia dysfunction

• no alternation in local cerebral glucose utilization in the cerebellum