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Phenotypes Associated with This Genotype
Genotype
MGI:4835496
Allelic
Composition
Mdm2tm3.1Glo/Mdm2tm3.1Glo
Genetic
Background
B6.129S6-Mdm2tm3.1Glo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm3.1Glo mutation (0 available); any Mdm2 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• overall survival is reduced relative to mice homozygous for Mdm2tm4.1Glo

cellular
• in the thymus following a low dose of IR radiation compared to mice homozygous for Mdm2tm4.1Glo and to wild-type mice
• MEFs display increase proliferation relative to mice homozygous for Mdm2tm4.1Glo

neoplasm
• accelerated tumor onset compared to mice homozygous for Mdm2tm4.1Glo

integument

endocrine/exocrine glands


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory