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Phenotypes Associated with This Genotype
Genotype
MGI:4835547
Allelic
Composition		 PrkcbM1Btlr/Prkcb+
Genetic
Background		 C57BL/6J-PrkcbM1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkcbM1Btlr mutation (1 available); any Prkcb mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:164864 )
• mice heterozygous for this mutation display a reduced IgM antibody response to the T cell-independent model antigen 2,4,6-trinitrophenyl (TNP)-Ficoll, intermediate between the responses of wild-type and homozygous mutant mice

hematopoietic system
decreased IgM level ( J:164864 )
• mice heterozygous for this mutation display a reduced IgM antibody response to the T cell-independent model antigen 2,4,6-trinitrophenyl (TNP)-Ficoll, intermediate between the responses of wild-type and homozygous mutant mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory