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Phenotypes Associated with This Genotype
Genotype
MGI:4835972
Allelic
Composition		 Tg(SOD1*G93A)dl1Gur/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SOD1*G93A)dl1Gur mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
microgliosis ( J:128738 )
• increased numbers of microglia in facial and hypoglossal nuclei at 8 months of age
astrocytosis ( J:128738 )
• increased numbers of reactive astrocytes in facial and hypoglossal nuclei at 8 months of age
decreased motor neuron number ( J:128738 )
• lower numbers of facial and hypoglossal motoneurons at 8 months of age
motor neuron degeneration ( J:128738 )
• atrophic facial and hypoglossal motoneurons at 8 months of age

immune system
microgliosis ( J:128738 )
• increased numbers of microglia in facial and hypoglossal nuclei at 8 months of age

hematopoietic system
microgliosis ( J:128738 )
• increased numbers of microglia in facial and hypoglossal nuclei at 8 months of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory