Analysis Tools
mortality/aging
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• some mice die between E12.5 and up to a few days after birth
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• some mice die between E12.5 and up to a few days after birth
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• some mice die between E12.5 and up to a few days after birth
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embryo
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• mice exhibit a developmental defect rather than uniform developmental delay
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• at E8.5
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• in 2 of 21 mice at E9.5
• in 5 of 16 mice at E10.5
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• mice exhibit abnormal somite development with numbers of somites ranging from 0 to 11 unlike in wild-type mice
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nervous system
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• in 2 of 21 mice at E9.5
• in 5 of 16 mice at E10.5
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• at E9.5, proliferation of forebrain neuroepithelium is increased compared to in wild-type mice
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cellular
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• one clone of ES cells is more sensitive than wild-type cells to gamma irradiation and mitomycin C
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• in one clone of ES cells
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growth/size/body
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• at E8.5
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