Phenotypes Associated with This Genotype

Genotype
MGI:4838160

• Allelic Composition: Ccn2^tm2Mae/Ccn2⁺; Tg(EIIa-cre)C5379Lmgd/?
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:165111 )

• Background Sensitivity: no heterozygous embryos after E12.5

embryo

abnormal pharyngeal arch development ( J:165111 )

• pharyngeal arches remain open

embryonic growth retardation ( J:165111 )

• small and embryonic development is delayed at E10.5

cardiovascular system

abnormal vasculogenesis ( J:165111 )

• less visible vasculature

craniofacial

abnormal facial morphology ( J:165111 )

• shortened face in mice surviving to adulthood (4/81)

small ears ( J:165111 )

• in mice surviving to adulthood (4/81)

limbs/digits/tail

short tail ( J:165111 )

• in mice surviving to adulthood (4/81)

kinked tail ( J:165111 )

• in mice surviving to adulthood (4/81)

skeleton

abnormal bone structure ( J:165111 )

• smaller bone area in mice surviving to adulthood (4/81)

decreased bone mineral content ( J:165111 )

• in mice surviving to adulthood (4/81)

growth/size/body

abnormal facial morphology ( J:165111 )

• shortened face in mice surviving to adulthood (4/81)

small ears ( J:165111 )

• in mice surviving to adulthood (4/81)

embryonic growth retardation ( J:165111 )

• small and embryonic development is delayed at E10.5

decreased lean body mass ( J:165111 )

• in mice surviving to adulthood (4/81)

hearing/vestibular/ear

small ears ( J:165111 )

• in mice surviving to adulthood (4/81)