Phenotypes for Cfp Lyz2 MGI:4838306 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cfp^tm2.1Song/Cfp^tm2.1Song Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfp^tm2.1Song mutation (0 available); any Cfp mutation (5 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired complement alternative pathway ( J:165497 )

• LPS-induced alternative pathway (AP) complement activation is impaired unlike in wild-type mice

decreased susceptibility to induced arthritis ( J:165497 )

• in a K/BxN model

skeleton

decreased susceptibility to induced arthritis ( J:165497 )

• in a K/BxN model

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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