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Phenotypes Associated with This Genotype
Genotype
MGI:4838777
Allelic
Composition		 Faslpr/Faslpr
Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic
Background		 MRL.Cg-Ifngr1tm1Agt Faslpr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (39 available); any Fas mutation (82 available)
Ifngr1tm1Agt mutation (13 available); any Ifngr1 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgA level ( J:92084 )
• compared with Faslpr homozygotes
decreased IgG2a level ( J:92084 )
• compared with Faslpr homozygotes
decreased IgG2b level ( J:92084 )
• compared with Faslpr homozygotes
decreased IgG3 level ( J:92084 )
• compared with Faslpr homozygotes
increased IgG level ( J:92084 )
• some mice exhibit IgG deposits in the kidney unlike wild-type mice
increased IgG1 level ( J:92084 )
• compared with Faslpr homozygotes
decreased IgM level ( J:92084 )
• compared with Faslpr homozygotes
small lymph nodes ( J:92084 )
• compared with Faslpr homozygotes
decreased susceptibility to systemic lupus erythematosus ( J:92084 )
• mice exhibit reduced serum levels of kappa-chain rheumatoid factor and DNA auto-antibodies, lymphadenopathy, glomerulonephritis, renal immunoglobulin deposits, proteinuria, and end organ disease compared with Faslpr homozygotes
decreased autoantibody level ( J:92084 )
• mice exhibit reduced serum levels of kappa-chain rheumatoid factor and DNA auto-antibodies compared to in Ifnar1tm1Agt homozygotes
decreased anti-nuclear antigen antibody level ( J:92084 )
• DNA auto-antibodies (likely against single stranded DNA) are decreased compared with Faslpr homozygotes
glomerulonephritis ( J:92084 )
• in some mice

renal/urinary system
glomerulonephritis ( J:92084 )
• in some mice

homeostasis/metabolism

hematopoietic system
decreased IgA level ( J:92084 )
• compared with Faslpr homozygotes
decreased IgG2a level ( J:92084 )
• compared with Faslpr homozygotes
decreased IgG2b level ( J:92084 )
• compared with Faslpr homozygotes
decreased IgG3 level ( J:92084 )
• compared with Faslpr homozygotes
increased IgG level ( J:92084 )
• some mice exhibit IgG deposits in the kidney unlike wild-type mice
increased IgG1 level ( J:92084 )
• compared with Faslpr homozygotes
decreased IgM level ( J:92084 )
• compared with Faslpr homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory