Phenotypes Associated with This Genotype

Genotype
MGI:4838970

• Allelic Composition: Slc1a2^tm1Kta/Slc1a2⁺; Tg(SOD1*G93A)1Gur/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:144898 )

• shortened lifespan (137 1.7 vs. 142 1.4 days)

cellular

abnormal cell physiology ( J:144898 )

• reduced glutamate transport in lumbar spinal cord at 120 days of age, compare with Tg(SOD1*G93A)1Gur mice

nervous system

decreased motor neuron number ( J:144898 )

• increase in the rate of motor decline accompanied by earlier motor neuron loss

• accelerated motor neuron loss at 120 days of age, compare with Tg(SOD1*G93A)1Gur mice

• significant declines occur between 105 and 120 days (42% reduction) and between 120 days and end stage, compared with between 120 days and endstage (56%) in Tg(SOD1*G93A)1Gur mice