Phenotypes Associated with This Genotype

Genotype
MGI:4839922

• Allelic Composition: Stat5b^tm1Mam/Stat5b^tm1Mam; Tg(Lck-cre)I57Jxm/0
• Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:122463 )

• splenomegaly starting at the age of 4 weeks

abnormal T cell subpopulation ratio ( J:122463 )

• increased ratio of CD4+ versus CD8+ cells in thymus, peripheral blood, spleen, and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:122463 )

• reduction of CD8+ T cells in thymus, peripheral blood, spleen and lymph nodes

abnormal acute inflammation ( J:122463 )

• lymphoid organ infiltration starting at the age of 4 weeks

hematopoietic system

enlarged spleen ( J:122463 )

• splenomegaly starting at the age of 4 weeks

abnormal T cell subpopulation ratio ( J:122463 )

• increased ratio of CD4+ versus CD8+ cells in thymus, peripheral blood, spleen, and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:122463 )

• reduction of CD8+ T cells in thymus, peripheral blood, spleen and lymph nodes

growth/size/body

enlarged spleen ( J:122463 )

• splenomegaly starting at the age of 4 weeks