Phenotypes Associated with This Genotype

Genotype
MGI:4840005

• Allelic Composition: Stat5a^tm2Mam/Stat5a^tm2Mam; Stat5b^tm1Mam/Stat5b^tm1Mam; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

obese ( J:127051 )

• mild obesity

• weigh on the average 20% more than their control littermates by 9 months of age

adipose tissue

increased total body fat amount ( J:127051 )

• elevated adipose tissue mass of female mice

• normal lean mass

homeostasis/metabolism

decreased insulin secretion ( J:127051 )

• reduced insulin secretion from isolated islets upon challenge with 16.7 mM of glucose

increased circulating glucose level ( J:127051 )

• slightly elevated serum glucose levels at 7 months of age

increased circulating leptin level ( J:127051 )

• higher serum leptin levels at 7 months of age

• normal serum insulin levels

increased circulating free fatty acids level ( J:127051 )

• higher serum free fatty acids levels at 7 months of age

impaired glucose tolerance ( J:127051 )

• higher glucose levels than the controls at all time points after glucose injection

• severity of impaired glucose response increases in both female and male mice as they age

• more severe than that seen in Tg(Ins2-cre)25Mgn mice

endocrine/exocrine glands

disorganized pancreatic islets ( J:127051 )

• disrupted architecture of islets as evidenced by the migration of glucagon-expressing alpha-cells into the central region of the islets

decreased insulin secretion ( J:127051 )

• reduced insulin secretion from isolated islets upon challenge with 16.7 mM of glucose