Phenotypes Associated with This Genotype

Genotype
MGI:4840008

• Allelic Composition: Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:127051 )

• reduced insulin secretion from isolated islets upon challenge with 16.7 mM of glucose

impaired glucose tolerance ( J:127051 )

• glucose intolerance as early as 6 weeks of age

endocrine/exocrine glands

decreased insulin secretion ( J:127051 )

• reduced insulin secretion from isolated islets upon challenge with 16.7 mM of glucose