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Phenotypes Associated with This Genotype
Genotype
MGI:4840009
Allelic
Composition		 Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5atm2Mam mutation (1 available); any Stat5a mutation (48 available)
Stat5btm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
disorganized pancreatic islets ( J:127051 )
• disrupted architecture of islets as evidenced by the migration of glucagon-expressing alpha-cells into the central region of the islets

homeostasis/metabolism
impaired glucose tolerance ( J:127051 )
• mild glucose intolerance in mice older than 6 months
• slightly more glucose intolerant during pregnancy than their control littermates

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory