Phenotypes for Stat5b Tg(Pdx1-cre)89.1Dam MGI:4840010 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Pdx1-cre)89.1Dam/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5b^tm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

disorganized pancreatic islets ( J:127051 )

• disrupted architecture of islets as evidenced by the migration of glucagon-expressing alpha-cells into the central region of the islets

homeostasis/metabolism

impaired glucose tolerance ( J:127051 )

• mild glucose intolerance in mice older than 6 months

• slightly more glucose intolerant during pregnancy than their control littermates

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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