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Phenotypes Associated with This Genotype
Genotype
MGI:4840038
Allelic
Composition		 Hprt1tm1(tetO-Runx1,-EGFP)Enk/Hprt1+
Sox10tm2(rtTA)Weg/Sox10+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(tetO-Runx1,-EGFP)Enk mutation (0 available); any Hprt1 mutation (1281 available)
Sox10tm2(rtTA)Weg mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:165939 )
• doxycycline-treated mice die 2 to 3 days after birth

nervous system
small dorsal root ganglion ( J:165939 )
• in doxycycline-treated mice

digestive/alimentary system
megacolon ( J:165939 )
• in doxycycline-treated mice

behavior/neurological
hyperresponsive to tactile stimuli ( J:165939 )
• in doxycycline-treated mice after a chronic constriction injury

growth/size/body
decreased birth body size ( J:165939 )
• in doxycycline-treated mice

pigmentation
abnormal skin pigmentation ( J:165939 )
• at birth in doxycycline-treated mice

integument
abnormal skin pigmentation ( J:165939 )
• at birth in doxycycline-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory