Phenotypes Associated with This Genotype

Genotype
MGI:4840275

• Allelic Composition: Stat5a^tm2Mam/Stat5a^tm2Mam; Stat5b^tm1Mam/Stat5b^tm1Mam; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased lean body mass ( J:132806 )

• increase 40% and 20% in male and female mice, respectively at 22 weeks of age

obese ( J:132806 )

• gain more weight than control littermates starting from 8 weeks of age

• more profound after 16 weeks of age

• weigh on the average 65% (males) and 60% (females) more at 26 weeks of age

behavior/neurological

polyphagia ( J:132806 )

• increased food intake in male at 16 weeks of age

• increased food intake in both male and female at 26 weeks of age

homeostasis/metabolism

impaired adaptive thermogenesis ( J:132806 )

• reduced cold tolerance at 26 weeks of age

increased circulating insulin level ( J:132806 )

• 8-fold at 22 weeks of age

increased circulating leptin level ( J:132806 )

• 4.5-fold at 22 weeks of age

increased circulating free fatty acids level ( J:132806 )

• at 22 weeks of age

increased circulating triglyceride level ( J:132806 )

• at 22 weeks of age

decreased oxygen consumption ( J:132806 )

• reduced oxygen consumption normalized to lean mass in male mice at 26 weeks of age

impaired glucose tolerance ( J:132806 )

• at 22 weeks of age

insulin resistance ( J:132806 )

• at 22 weeks of age

adipose tissue

increased total body fat amount ( J:132806 )

• increase 2.5- and 3.5-fold in male and female mice, respectively at 22 weeks of age

• increase in both subcutaneous and visceral fat mass

abnormal fat pad morphology ( J:132806 )

• larger mean cross-sectional areas of adipocytes in inguinal, parametrial and mesenteric fat pads

increased total fat pad weight ( J:132806 )

• at least 2 fold increase in weight of all 5 fat pads (inguinal, parametrial, retroperitoneal, mesenteric and perirenal)

increased percent body fat/body weight ( J:132806 )

• 150% and 200% in male and female mice, respectively of that measured in control mice at 22 weeks of age