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Phenotypes Associated with This Genotype
Genotype
MGI:4840364
Allelic
Composition		 Rag2tm1Fwa/Rag2tm1Fwa
Tbatatm1Faf/Tbatatm1Faf
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
Tbatatm1Faf mutation (0 available); any Tbata mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased thymocyte number ( J:166065 )
• at 8 weeks
• 3- to 4-fold at 3 months
abnormal T cell differentiation ( J:166065 )
• thymocyte development arrests at the DN3 stage unlike in wild-type mice

hematopoietic system
increased thymocyte number ( J:166065 )
• at 8 weeks
• 3- to 4-fold at 3 months
abnormal T cell differentiation ( J:166065 )
• thymocyte development arrests at the DN3 stage unlike in wild-type mice
abnormal bone marrow cell physiology ( J:166065 )
• in reconstitution experiments, thymocyte numbers are increased and thymic reconstitution dependent on stromal cells is enhanced compared to when wild-type bone marrow is used

endocrine/exocrine glands
increased thymocyte number ( J:166065 )
• at 8 weeks
• 3- to 4-fold at 3 months

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory