Phenotypes Associated with This Genotype

Genotype
MGI:4843145

• Allelic Composition: Pcid2^tm1Imku/Pcid2^tm1Imku; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased mature B cell number ( J:166080 )

• severely reduced numbers of splenic B cells in the T1(Cd21^loCd24^hi) and T2 (Cd21^hiCd24^hi) stages

• B220+ cells markedly reduced, particularly in the follicular regions of the spleen

decreased follicular B cell number ( J:166080 )

• reduced numbers of Cd21^intCd24^lo cells

decreased marginal zone B cell number ( J:166080 )

• reduced numbers of Cd21^hiCd23^lo cells

abnormal spleen B cell follicle morphology ( J:166080 )

• reduced follicular region size

hematopoietic system

decreased mature B cell number ( J:166080 )

• severely reduced numbers of splenic B cells in the T1(Cd21^loCd24^hi) and T2 (Cd21^hiCd24^hi) stages

• B220+ cells markedly reduced, particularly in the follicular regions of the spleen

decreased follicular B cell number ( J:166080 )

• reduced numbers of Cd21^intCd24^lo cells

decreased marginal zone B cell number ( J:166080 )

• reduced numbers of Cd21^hiCd23^lo cells

abnormal spleen B cell follicle morphology ( J:166080 )

• reduced follicular region size