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Phenotypes Associated with This Genotype
Genotype
MGI:4843433
Allelic
Composition		 Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5atm2Mam mutation (1 available); any Stat5a mutation (48 available)
Stat5btm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating interleukin-17 level ( J:120176 )
• elevated serum IL-17 concentration

immune system
increased circulating interleukin-17 level ( J:120176 )
• elevated serum IL-17 concentration
increased interleukin-17 secretion ( J:120176 )
• increased amounts of IL-17 protein in the culture supernatants of CD4+ T cells activated with anti-CD3 and anti-CD28

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory