Phenotypes for Shh Tg(Mef2c-cre)2Blk MGI:4843920 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Shh^tm1Chg/Shh^tm2Chg Tg(Mef2c-cre)2Blk/0
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^tm1Chg mutation (2 available); any Shh mutation (48 available)
Shh^tm2Chg mutation (0 available); any Shh mutation (48 available)
Tg(Mef2c-cre)2Blk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:135134 )

N	• mice exhibit normal outflow tracts

abnormal artery morphology ( J:135134 )

• at E18.5, 4 of 16 mice exhibit abnormal arch-artery patterning compared with wild-type mice

persistent truncus arteriosus ( J:135134 )

• in 14 of 16 mice

• however, mice exhibit normal outflow tract length with no increase in apoptosis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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