Analysis Tools
hematopoietic system
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• microcytic, hypochromic anemia
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• red cell hypoplasia in bone marrow at E18.5
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• higher ratio of nucleated erythroid cells in fetuses and neonates
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• greatly reduced number of mature red blood cells in fetuses and neonates
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• decreased hematocrits of approximately 2.5 (25%) in neonates, compared with 4.7 (47%) in controls
• hematocrits in adult mutant mice remain low at 2.9
• decreased hematocrits of approximately 2.6 in mice that receive a transplant of mutant fetal liver cells, compared with 3.8 in controls
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• reduced red cell size (mean corpuscular volume) and hemoglobin content in mutant mice and in mice that receive a transplant of mutant fetal liver cells
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• increased red cell distribution width
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anisocytosis
(
J:138904
)
microcytosis
(
J:138904
)
homeostasis/metabolism
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• elevated serum iron levels and transferrin saturation in mutant mice and in mice that receive a transplant of mutant fetal liver cells
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• non-heme iron overload in the liver
• periportal hepatocyte iron staining
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cellular
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• elevated cell death in survival response of splenic Ter119-positive cells to erythropoietin
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liver/biliary system
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• non-heme iron overload in the liver
• periportal hepatocyte iron staining
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