Phenotypes Associated with This Genotype

Genotype
MGI:4844277

• Allelic Composition: Flt1^tm1Jrt/Flt1^tm1Jrt
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:26845 )

• no mice are observed after E9

cardiovascular system

abnormal vascular development ( J:26845 )

• only large fused vessels with internally localized groups of endothelial cells are present in the head mesenchyme instead of the small vessels observed in wild-type mice

abnormal dorsal aorta morphology ( J:26845 )

• contains endothelial cells within the lumen

abnormal vitelline vasculature morphology ( J:26845 )

• vascular structures are large and enclosed with endothelial cells compared to in wild-type mice

• however, endothelial cell formation is normal

disorganized yolk sac vascular plexus ( J:26845 )

abnormal heart development ( J:26845 )

• the endocardial lining of heart ventricles are thickened and disorganized compared to in wild-type mice

embryo

abnormal vitelline vasculature morphology ( J:26845 )

• vascular structures are large and enclosed with endothelial cells compared to in wild-type mice

• however, endothelial cell formation is normal

disorganized yolk sac vascular plexus ( J:26845 )

embryonic growth arrest ( J:26845 )

• at E8.5

abnormal visceral yolk sac blood island morphology ( J:26845 )

• blood-island structures are abnormal and disorganized compared to in wild-type mice