Phenotypes Associated with This Genotype

Genotype
MGI:4847595

• Allelic Composition: App^tm1Ck/App^tm1Ck; Psen1^tm1Mpm/Psen1^tm1Mpm
• Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:166379 )

• mice exhibit decreased amyloid load compared with App^tm3.1Zhe Psen1^tm1Mpm double homozygotes

abnormal brain morphology ( J:191170 )

• corticotropin releasing factor levels are increased in the lateral dorsal bed nucleus of the stria terminalis and the paraventricular nucleus

homeostasis/metabolism

amyloid beta deposits ( J:166379 )

• mice exhibit decreased amyloid load compared with App^tm3.1Zhe Psen1^tm1Mpm double homozygotes

increased circulating corticosterone level ( J:191170 )

• mice exhibit an increase in resting levels of circulating corticosterone

behavior/neurological

enhanced contextual conditioning behavior ( J:191170 )

• mice show increased freezing in the context in which they received the shock compared to wild-type mice but show similar levels of freezing as wild-type mice in cued fear (in response to sound), indicating increased contextual fear

• however, hot plate assay shows normal nociception

abnormal spatial working memory ( J:191170 )

• in the alternation T-maze test, mice show decreased alternation, indicating reduced working memory

increased anxiety-related response ( J:191170 )

• in the elevated plus maze, mice spend more time in the closed arms and less time in the open arms and make fewer entries into the open arms and navigate less distance on the open arms, indicating increased levels of anxiety

• in the light-dark box test, mice spend more time in the closed portion of the box and less time in the open side, make fewer entries to the light side of the box, and spend on average more time on each visit to the dark side, suggesting an increase in hiding behavior and reduction in exploring

• mice show increased freezing in the context in which they received the shock compared to wild-type mice but show similar levels of freezing as wild-type mice in cued fear (in response to sound)

• during the cued trial, mice show increased baseline freezing levels in the 3 minutes before presentation of sound, however increased baseline freezing is not seen before mice are shocked

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:191170