Phenotypes Associated with This Genotype

Genotype
MGI:4847654

• Allelic Composition: Gdf5^bp-H/Gdf5^bp-H
• Genetic Background: involves: PCT stock * Swiss albino

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal long bone epiphyseal plate morphology ( J:166507 )

• epiphyseal cartilage of the fibula obtained within 6 hours of birth is shorter than normal, unscuptured, and shows homogeneous distribution of chondrocytes throughout the rudiment, rather than the three distinct cellular zones of the normal control

abnormal cartilage development ( J:166507 )

• fibular cartilage obtained within 6 hours of birth shows decreased chondrocyte protein synthesis, aberrant metabolism of collagen and chondroitin sulfate, and morphological abnormalities

delayed endochondral bone ossification ( J:166507 )

• evident in fibulae assessed within 6 hours of birth