Phenotypes Associated with This Genotype

Genotype
MGI:4867271

• Allelic Composition: Lims1^tm1.1Chen/Lims1^tm1.1Chen; Tg(Tnnt2-cre)5Blh/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:167114 )

N • mice exhibit normal heart morphology and physiology under normal conditions

decreased cardiac muscle contractility ( J:167114 )

• following infarct induction

abnormal response to cardiac infarction ( J:167114 )

• following infarct induction, mice exhibit reduced fractional shortening and increased infarct size and scar tissue with hemorrhage compared with similarly treated wild-type mice

increased myocardial infarct size ( J:167114 )

homeostasis/metabolism

abnormal response to cardiac infarction ( J:167114 )

• following infarct induction, mice exhibit reduced fractional shortening and increased infarct size and scar tissue with hemorrhage compared with similarly treated wild-type mice

increased myocardial infarct size ( J:167114 )

muscle

decreased cardiac muscle contractility ( J:167114 )

• following infarct induction