Phenotypes Associated with This Genotype

Genotype
MGI:4867643

• Allelic Composition: Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:166928 )

nervous system

nervous system phenotype ( J:166928 )

N • mice exhibit normal gliogenesis

abnormal neuron differentiation ( J:166928 )

• the number of neuroblasts in the cortex is reduced compared to in wild-type mice

• at E16.5, neuron progenitor apoptosis in the tectal mantle layer is increased compared to in wild-type mice

• neurosphere apoptosis is increased compared to in wild-type mice

• differentiation of neurospheres in culture is blocked compared to cultured wild-type cells

abnormal brain development ( J:166928 )

• mice exhibit a reduction in the number of cells in regions of the brain occupied by committed progenitors and differentiated cells compared with wild-type mice

• areas containing immature cells exhibit normal or increased numbers of cells compared to in wild-type mice

abnormal cortical intermediate zone morphology ( J:166928 )

• the intermediate zone contains fewer cells than in wild-type mice

abnormal cortical plate morphology ( J:166928 )

• the cortical plate contains fewer cells than in wild-type mice

abnormal cerebellum development ( J:166928 )

• the cerebellar anlage contains fewer cells than in wild-type mice

abnormal tectum morphology ( J:166928 )

• the midbrain tectum, especially the tectal mantle, contains fewer cells than in wild-type mice

• the number of cells in the tectal ventricular zone is increased compared to in wild-type mice

thalamus hypoplasia ( J:166928 )

• the thalamus contains fewer cells than in wild-type mice

abnormal cerebral cortex morphology ( J:166928 )

• the forebrain cortex contains fewer cells than in wild-type mice

abnormal embryonic/fetal subventricular zone morphology ( J:166928 )

• the cortical subventricular zone contains fewer cells than in wild-type mice

decreased neuronal precursor cell number ( J:166928 )

• smaller and fewer without a defect in proliferation

cellular

abnormal neuron differentiation ( J:166928 )

• the number of neuroblasts in the cortex is reduced compared to in wild-type mice

• at E16.5, neuron progenitor apoptosis in the tectal mantle layer is increased compared to in wild-type mice

• neurosphere apoptosis is increased compared to in wild-type mice

• differentiation of neurospheres in culture is blocked compared to cultured wild-type cells