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Phenotypes Associated with This Genotype
Genotype
MGI:4867644
Allelic
Composition		 Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe
Juntm4Wag/Jun+
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1.1Axbe mutation (4 available); any Fbxw7 mutation (84 available)
Juntm4Wag mutation (0 available); any Jun mutation (12 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron apoptosis ( J:166928 )
• neurosphere apoptosis is decreased compared to in Fbxw7tm1Axbe/Fbxw7tm1Axbe Tg(Nes-cre)1Kln mice
abnormal tectum morphology ( J:166928 )
• the cellularity defect in the mantle layer of the midbrain tectum observed in Fbxw7tm1Axbe/Fbxw7tm1Axbe Tg(Nes-cre)1Kln mice is rescued
• the number of stem cells in the tectal ventricular zone is increased compared to in wild-type mice

cellular
abnormal neuron apoptosis ( J:166928 )
• neurosphere apoptosis is decreased compared to in Fbxw7tm1Axbe/Fbxw7tm1Axbe Tg(Nes-cre)1Kln mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory