Phenotypes Associated with This Genotype

Genotype
MGI:4878939

• Allelic Composition: Fli1^tm1Morl/Fli1^tm1Morl; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129/Sv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:167426 )

N • gene deletion frequency of 60-90% after pIpC injection

abnormal megakaryocyte differentiation ( J:167426 )

• marked decrease in the ratio of mature to immature megakaryocytes among bone marrow cells

• 10 fold decrease in CFU-MK in bone marrow

abnormal erythropoiesis ( J:167426 )

abnormal thrombopoiesis ( J:167426 )

increased erythroid progenitor cell number ( J:167426 )

• BFU-E and CFU-E are increased

increased erythrocyte cell number ( J:167426 )

• increased erythrocytic cells

thrombocytopenia ( J:167426 )

• 33% decrease in the mean number of platelets in the circulation

• mild thrombocytopenia

abnormal leukocyte morphology ( J:167426 )

decreased granulocyte number ( J:167426 )

• decreased granulocytes

• CFU-G are decreased

increased NK cell number ( J:167426 )

increased monocyte cell number ( J:167426 )

• CFU-M are increased

immune system

abnormal thrombopoiesis ( J:167426 )

abnormal leukocyte morphology ( J:167426 )

decreased granulocyte number ( J:167426 )

• decreased granulocytes

• CFU-G are decreased

increased NK cell number ( J:167426 )

increased monocyte cell number ( J:167426 )

• CFU-M are increased

cellular

abnormal megakaryocyte differentiation ( J:167426 )

• marked decrease in the ratio of mature to immature megakaryocytes among bone marrow cells

• 10 fold decrease in CFU-MK in bone marrow