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Phenotypes Associated with This Genotype
Genotype
MGI:4882149
Allelic
Composition		 Foxo3tm1Rdp/Foxo3tm1Rdp
Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo3tm1Rdp mutation (1 available); any Foxo3 mutation (51 available)
Tg(Ddx4-cre/ERT2)1Dcas mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal primordial ovarian follicle morphology ( J:138697 )
• mutants treated with tamoxifen to induce cre expression exhibit global follicle activation
enlarged ovary ( J:138697 )
• mutants treated with tamoxifen to induce cre expression exhibit ovarian hypertrophy

reproductive system
abnormal primordial ovarian follicle morphology ( J:138697 )
• mutants treated with tamoxifen to induce cre expression exhibit global follicle activation
enlarged ovary ( J:138697 )
• mutants treated with tamoxifen to induce cre expression exhibit ovarian hypertrophy

growth/size/body
enlarged ovary ( J:138697 )
• mutants treated with tamoxifen to induce cre expression exhibit ovarian hypertrophy

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory