Analysis Tools
mortality/aging
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• about 10% of mutants exhibit a mosaic skin phenotype and survive for months
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• about 90% of mutants die by P15, while 10% survive for months
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integument
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• mutants exhibit an increase in epidermal water loss
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dermatitis
(
J:167299
)
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• mutants develop atopic dermatitis-like skin disease
• about 90% of mutants exhibit a uniform skin phenotype and die by P15 while mutants that survive longer than P15, exhibit the skin phenotype on the posterior region of the back skin
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• 2.5-fold increase in the numbers of blood vessels in the skin as indicated by marker analysis
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• 2.5-fold increase in the numbers of blood vessels in the skin as indicated by marker analysis
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skin edema
(
J:167299
)
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• cutaneous edema is seen in the ears and feet
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• affected skin of mutants surviving longer than P15 shows suprabasal cells with increased intracellular space, indicating development of spongiosis
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• hyperproliferation of epithelial stem/progenitor cells in the skin
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acanthosis
(
J:167299
)
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• the intracellular adhesion apparatus of the epidermis is disrupted, with keratinocytes showing an abnormal punctate localization of E-cadherin (Cdh1) due to increased shedding of E-cadherin
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• mutants exhibit epidermal hyperplasia
• topical application of clobetasol, a corticosteroid, substantially reduces the epidermal hyperplasia and abolishes the epidermal gaps
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scaly skin
(
J:167299
)
immune system
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• mutants exhibit an increase in mast cells with age
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• IgE levels are normal in young mutants but adults show a 30-fold increase compared to wild-type mice
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• 5-fold increase in serum IgG1 levels in adults
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• marker analysis indicates that mutants exhibit a biphastic T-helper cell response, with a TH2 response during the acute phase of dermatitis followed by a TH1 response during the chronic phase of dermatitis
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dermatitis
(
J:167299
)
|
• mutants develop atopic dermatitis-like skin disease
• about 90% of mutants exhibit a uniform skin phenotype and die by P15 while mutants that survive longer than P15, exhibit the skin phenotype on the posterior region of the back skin
|
homeostasis/metabolism
skin edema
(
J:167299
)
|
• cutaneous edema is seen in the ears and feet
|
|
• affected skin of mutants surviving longer than P15 shows suprabasal cells with increased intracellular space, indicating development of spongiosis
|
|
• mutants exhibit an increase in epidermal water loss
|
hematopoietic system
|
• mutants exhibit an increase in mast cells with age
|
|
• IgE levels are normal in young mutants but adults show a 30-fold increase compared to wild-type mice
|
|
• 5-fold increase in serum IgG1 levels in adults
|
|
• marker analysis indicates that mutants exhibit a biphastic T-helper cell response, with a TH2 response during the acute phase of dermatitis followed by a TH1 response during the chronic phase of dermatitis
|
cardiovascular system
|
• 2.5-fold increase in the numbers of blood vessels in the skin as indicated by marker analysis
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| atopic dermatitis | DOID:3310 |
OMIM:603165 OMIM:PS603165 |
J:167299 | |
