Phenotypes Associated with This Genotype

Genotype
MGI:4939802

• Allelic Composition: Il6st^tm1Ern/Il6st^tm1Ern
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:168781 )

• mice fail to survive beyond 72 hours after treatment with an LPS dose that is sub-lethal to wild-type mice

immune system

increased neutrophil cell number ( J:168781 )

• LPS-treated mice exhibit a 4-fold increase in neutrophil influx into the peritoneal cavity with a 2-fold increase in the neutrophil-attractant CXCL11 compared with similarly treated wild-type mice

increased circulating interleukin-6 level ( J:168781 )

• LPS-treated mice exhibit a 3.5- and 2-fold (at 3 and 6 hours) increase in serum IL6 levels compared with similarly treated wild-type mice

increased interleukin-6 secretion ( J:168781 )

• LPS-treated mice exhibit a 3- and 34-fold (at 3 and 6 hours) increase in IL6 at the site of injection compared with similarly treated wild-type mice

increased susceptibility to endotoxin shock ( J:168781 )

• LPS-treated mice exhibit an increase in serum IL6 (3.5-fold at 3 hours, 2-fold at 6 hours), IL6 secretion into the peritoneal cavity (3-fold at 3 hours, 32-fold at 6 hours), neutrophil infiltration into the peritoneal cavity, and increased mortality compared with similarly treated wild-type mice

• however, LPS-induced IL10 production is normal

homeostasis/metabolism

increased circulating interleukin-6 level ( J:168781 )

• LPS-treated mice exhibit a 3.5- and 2-fold (at 3 and 6 hours) increase in serum IL6 levels compared with similarly treated wild-type mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:168781 )

• mice fail to survive beyond 72 hours after treatment with an LPS dose that is sub-lethal to wild-type mice

hematopoietic system

increased neutrophil cell number ( J:168781 )

• LPS-treated mice exhibit a 4-fold increase in neutrophil influx into the peritoneal cavity with a 2-fold increase in the neutrophil-attractant CXCL11 compared with similarly treated wild-type mice