About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4940206
Allelic
Composition		 Plcg2tm1Jni/Plcg2tm1Jni
Tg(IghMyc)22Bri/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg2tm1Jni mutation (2 available); any Plcg2 mutation (74 available)
Tg(IghMyc)22Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:117023 )
• mean mortality is 10 weeks

immune system
enlarged lymph nodes ( J:117023 )
• by 8 weeks

neoplasm
increased lymphoma incidence ( J:117023 )
• development of lymphoma is accelerated compared to in Tg(IghMyc)22Bri mice
increased B cell derived lymphoma incidence ( J:117023 )
• lymphomas are composed of large pre-B cells unlike in Tg(IghMyc)22Bri mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory