vision/eye
• at E15.5
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• reduced
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• thickened cornea
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• eyes are rotated such that the medial-lateral eye axis is 45 degree angle to the dorsal-ventral axis of the head unlike in wild-type mice
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• at P35, mice exhibit extreme small eye size and decreased eye weight compared with wild-type mice
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nervous system
• mice exhibit reduced diameter of the marginal zone in the dorsal pallial region compared with wild-type mice
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• mice exhibit increased diameter of the ventricular and subventricular zone compared with wild-type mice
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• mice exhibit hypoplasia in the telencephalic frontal area compared with wild-type mice
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• mice exhibit increased diameter of the ventricular and subventricular zone compared with wild-type mice
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growth/size/body
pigmentation
N |
• mice exhibit normal belly pigmentation
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• reduced
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