About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4948946
Allelic
Composition		 Parp1tm1Jmdm/Parp1tm1Jmdm
Parp3tm1.2Ics/Parp3tm1.2Ics
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Parp1tm1Jmdm mutation (1 available); any Parp1 mutation (66 available)
Parp3tm1.2Ics mutation (1 available); any Parp3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased mortality induced by ionizing radiation ( J:170941 )
• 126 days postirradiation, only 4 of 11 mice survive compared with 7 of 9 Parp1tm1Jmdm homozygotes

homeostasis/metabolism
increased mortality induced by ionizing radiation ( J:170941 )
• 126 days postirradiation, only 4 of 11 mice survive compared with 7 of 9 Parp1tm1Jmdm homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory