Phenotypes for Adgra2 Tg(Tek-cre)12Flv MGI:4949906 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Adgra2^tm1.1Bstc/Adgra2^tm1.2Bstc Tg(Tek-cre)12Flv/0
Genetic Background	B6.Cg-Adgra2^tm1.1Bstc/Adgra2^tm1.2Bstc Tg(Tek-cre)12Flv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgra2^tm1.1Bstc mutation (1 available); any Adgra2 mutation (43 available)
Adgra2^tm1.2Bstc mutation (0 available); any Adgra2 mutation (43 available)
Tg(Tek-cre)12Flv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal brain vasculature morphology ( J:171226 )

• at E12.5 glomeruloid bodies form in the lateral ventricle wall in the region adjacent to the ganglionic eminence, similar to what is seen in Gpr124^tm1.2Bstc homozygotes

intracranial hemorrhage ( J:171226 )

spinal hemorrhage ( J:171226 )

nervous system

abnormal brain vasculature morphology ( J:171226 )

• at E12.5 glomeruloid bodies form in the lateral ventricle wall in the region adjacent to the ganglionic eminence, similar to what is seen in Gpr124^tm1.2Bstc homozygotes

intracranial hemorrhage ( J:171226 )

spinal hemorrhage ( J:171226 )

abnormal telencephalon development ( J:171226 )

• failure of neocortex development

abnormal pallium development ( J:171226 )

• notably thinner at E15.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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