Phenotypes Associated with This Genotype

Genotype
MGI:4950707

• Allelic Composition: Pecam1^tm1Mak/Pecam1^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

decreased lung endothelial cell migration ( J:110561 )

• neonatal mutant lungs show a significant reduction in wound-induced endothelial cell (EC) migration relative to wild-type lungs

• however, no significant differences in lung EC content, proliferation or survival are observed

abnormal lung morphology ( J:110561 )

• although appropriately inflated, mutant lungs display a very disorganized architecture at P1

impaired lung alveolus development ( J:110561 )

• postnatal mutant lungs display evidence of arrested/delayed alveolarization

• at P7, secondary septation appears to be retarded relative to wild type mice

• by 8 weeks of age (adult), differences in alveolarization are smaller but still present

• at P1, P7 and at 8 weeks (adult), mean alveolar areas are significantly increased while radial alveolar counts are significantly reduced, indicating impaired alveolarization

• however, no significant differences in alveolar cell apoptosis are observed by TUNEL staining

abnormal pulmonary alveolar sac morphology ( J:110561 )

• at P1, mutant primary alveolar sacs are larger than wild-type

increased pulmonary alveolus wall thickness ( J:110561 )

• at P1, mutant alveolar walls are thicker than wild-type

cellular

decreased lung endothelial cell migration ( J:110561 )

• neonatal mutant lungs show a significant reduction in wound-induced endothelial cell (EC) migration relative to wild-type lungs

• however, no significant differences in lung EC content, proliferation or survival are observed