Phenotypes Associated with This Genotype

Genotype
MGI:4999726

• Allelic Composition: Hhex^tm1.1Tmj/Hhex⁺
• Genetic Background: involves: 129S1/Sv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Anterior visceral endoderm defects in Hhex^tm1.1Tmj/Hhex⁺ embryos

mortality/aging

abnormal survival ( J:171680 )

• half of expected mice die between E9.5 and weaning

• however, mice that survive to adulthood are normal

preweaning lethality, incomplete penetrance ( J:171680 )

• half of expected mice die between E9.5 and weaning

embryo

embryonic growth retardation ( J:171680 )

• in some mice at E6.5 and E7.5

abnormal egg cylinder morphology ( J:171680 )

• small and disorganized in some mice at E6.5 and E7.5

abnormal primitive streak morphology ( J:171680 )

• mice exhibit impaired primitive streak patterning as determined by marker expression compared with wild-type mice

abnormal anterior visceral endoderm morphology ( J:171680 )

• mice exhibit reduced expression of anterior visceral endoderm markers compared with wild-type mice

nervous system

abnormal forebrain morphology ( J:171680 )

• at E8.5 and E9.5, forebrain patterning is abnormal compared to in wild-type mice

growth/size/body

embryonic growth retardation ( J:171680 )

• in some mice at E6.5 and E7.5