Phenotypes Associated with This Genotype

Genotype
MGI:5000011

• Allelic Composition: Col1a1^{tm10(tetO*-RFP/RNAi:Rpa3)Slowe}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:171348 )

• all mice treated with doxycycline between 5 and 10 weeks of age die prematurely

digestive/alimentary system

abnormal small intestinal crypt cell physiology ( J:171348 )

• doxycycline-treated adult mice exhibit atrophy of intestinal epithelium unlike control mice

• however, withdrawal of doxycycline reverses villus atrophy

abnormal small intestinal crypt cell proliferation ( J:171348 )

• doxycycline-treated adult mice exhibit decreased proliferation and cell cycle arrest in the intestinal epithelium unlike control mice

hematopoietic system

decreased erythroid progenitor cell number ( J:171348 )

• doxycycline-treated adult mice exhibit decreased erythroid precursors in the bone marrow unlike in control mice

growth/size/body

weight loss ( J:171348 )

• in doxycycline-treated adult mice

• however, mice regain weight after withdrawal of doxycycline

cellular

abnormal small intestinal crypt cell proliferation ( J:171348 )

• doxycycline-treated adult mice exhibit decreased proliferation and cell cycle arrest in the intestinal epithelium unlike control mice